Proteins

Proteins are the "workhorse" molecules of life, taking part in essentially every structure and activity of life. They are building materials for living cells, appearing in the structures inside the cell and within the cell membrane. They carry oxygen, they build tissue, they copy DNA for the next generation - they do all the work in any organism. While many of the proteins are structural proteins, many are regulatory proteins called enzymes.

They contain carbon, hydrogen, and oxygen like the carbohydrates and lipids, but they also contain nitrogen and often sulfur and phosphorus.

Protein molecules are often very large and are made up of hundreds to thousands of amino acid units. Though large, the protein typically has a small working region, such as a pocket located on the three-dimensional surface of the folded protein chain which acts as a binding site. The 20 amino acids are combined in different ways to make up the 100,000 or so different proteins in the human body. Some of these proteins are in solution in the blood and other fluids of the body, and some are in solid form as the framework of tissue, bone and hair. Shipman, et al. suggests that they make up about 75% of the dry weight of our bodies.

Proteins can be characterized as extremely long-chain polyamides. The amides contain nitrogen, and nitrogen composes about 16% of the protein atomic content. These proteins are created in the body by condensation of amino acids under the influence of enzyme catalysts, using patterns or direction from the nucleic acids in the cells.

The amino acid units in a protein molecule are held together by peptide bonds, and form chains called polypeptide chains. The sequencing of the 20 amino acids forms a kind of alphabet for expression of the type of protein, leading to a very large number of types of proteins.

In the cell, the DNA directs or provides the master blueprint for creating proteins, using transcription of information to mRNA and then translation to actually create proteins.

A comment from Miller "Living things, after all are constructed by the execution of a series of genetic messages encoded in DNA. Genes, the functional units of that genetic program, generally encode proteins, which are the workhorses of the cell. As our exploration of the genomes of humans and other organisms expands, it becomes clear that those proteins can do just about everything required to produce an organism ..."

Wiki: protein structure

Index

Biochemical concepts

Chemistry concepts

Reference
Shipman, Wilson and Todd
Ch 15

Reference
Miller
Ch 2
 
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Structural Proteins

Protein molecules are often very large and are made up of hundreds to thousands of amino acid units. The 20 amino acids are combined in different ways to make up the 100,000 or so different proteins in the human body. Some of these proteins are in solution in the blood and other fluids of the body, and some are in solid form as the framework of tissue, bone and hair. Shipman, et al. suggests that they make up about 75% of the dry weight of our bodies.

Proteins can be characterized as extremely long-chain polyamides. The amides contain nitrogen, and nitrogen composes about 16% of the protein atomic content. These proteins are created in the body by condensation of amino acids under the influence of enzyme catalysts, using patterns or direction from the nucleic acids in the cells.

Index

Biochemical concepts

Chemistry concepts

Reference
Shipman, Wilson and Todd
Ch 15
 
HyperPhysics*****Chemistry R Nave
Go Back